ea0077oc1.4 | Reproductive and Neuroendocrinology | SFEBES2021
Mills Edouard G
, Swedrowska Magda
, Thurston Layla
, Phylactou Maria
, Patel Bijal
, Clarke Sophie A
, Yang Lisa
, Muzi Beatrice
, Choudhry Muhammad
, Alexander Emma
, Abbara Ali
, Forbes Ben
, Comninos Alexander N
, Dhillo Waljit S
Background: Kisspeptin is a critical activator of hypothalamic gonadotrophin-releasing hormone neurons, inducing release of downstream reproductive hormones. Intravenous or subcutaneous kisspeptin administration has been shown to have significant potential to treat reproductive disorders. However, intranasal administration could offer a novel non-invasive delivery route, which would be clinically preferable. We therefore sought to determine the effects of intranasal kisspeptin...